RNF43 interacts with NEDL1 and regulates p53-mediated transcription

► RNF43 binds to NEDD-4-like ubiquitin-protein ligase-1 (NEDL1). ► RNF43 interacts with p53 and suppresses transcriptional activity of p53. ► RNF43 attenuates apoptosis induced by ultraviolet irradiation. ► RNF43 is likely associated with p53-mediated apoptosis in collaboration with NEDL1 in colorectal carcinogenesis.