Down-regulation of connexin43 gap junction by serum deprivation in human endothelial cells was improved by (−)-Epigallocatechin gallate via ERK MAP kinase pathway

► EGCG ameliorates the GJIC-inhibitory effect of serum deprivation. ► Recovery of GJIC activity by EGCG depends on Cx43. ► EGCG activates MAPK and PI3K/Akt/eNOS pathway. ► EGCG improves Cx43 gap junction via the activation of ERK MAPK.