کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10764489 | 1050549 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The intracellular stability of DLC1 is regulated by the 26S proteasome in human hepatocellular carcinoma cell line Hep3B
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The intracellular stability of DLC1 is regulated by the 26S proteasome in human hepatocellular carcinoma cell line Hep3B The intracellular stability of DLC1 is regulated by the 26S proteasome in human hepatocellular carcinoma cell line Hep3B](/preview/png/10764489.png)
چکیده انگلیسی
⺠The proteasome inhibitor MG132 increases the levels of both endogenous and exogenous DLC1 proteins in HEK293 and Hep3B cells. ⺠DLC1 is an unstable protein that is degraded by the 26S proteasome in Hep3B cells. ⺠Five putative PEST motifs are located in the N-terminus of DLC1. ⺠Deletion of the PEST motifs decreases the intracellular stability of the N-terminus of DLC1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 404, Issue 1, 7 January 2011, Pages 279-283
Journal: Biochemical and Biophysical Research Communications - Volume 404, Issue 1, 7 January 2011, Pages 279-283
نویسندگان
Hong-wei Luo, Qiu-ping Luo, Ying Yuan, Xiao-ying Zhu, Shi-feng Huang, Zhi Peng, Chun-li Li, Zong-gan Huang, Wen-li Feng,