Nitrosative stress-induced Parkinsonian Lewy-like aggregates prevented through polyphenolic phytochemical analog intervention

► Nitrosative stress and PDI damage is known to be associated with PD/AD. ► EF-24, a curcumin analog can scavenge NOx. ► EF-24 can prevent synphilin-1 aggregation in dopaminergic SHSY-5Y cells. ► EF-24 restores PDI expression levels under nitrosative stress conditions.