Regulation of ENT1 expression and ENT1-dependent nucleoside transport by c-Jun N-terminal kinase

► Stress-activated kinases downregulate the expression of several transporters. ► JNK activation and c-Jun phosphorylation downregulate mENT1 expression. ► mENT1 promoter contains an AP1 binding site and cJun is able to bind mENT1 promoter. ► JNK signaling pathway regulates mENT1 expression.