Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans

► AMPK activity is lower in visceral than in subcutaneous adipose tissue of obese humans. ► Inflammatory gene expression is higher in visceral adipose tissue. ► AMPK activity is lower in adipose tissue of insulin-resistant obese than in insulin sensitive obese patients.