Unique “delta lock” structure of telmisartan is involved in its strongest binding affinity to angiotensin II type 1 receptor

► Telmisartan was the strongest ARB for the reduction of BP in patients with essential hypertension. ► Telmisartan had a unique binding mode to the AT1 receptor due to its distal benzimidazole portion. ► Due to its “delta lock” structure, telmisartan may be superior to other ARBs in halting cardiovascular disease in patients with hypertension.