The MAP kinase Pmk1 and protein kinase A are required for rotenone resistance in the fission yeast, Schizosaccharomyces pombe

► Rotenone induces generation of ROS and mitochondrial fragmentation in fission yeast. ► The MAPK Pmk1 and PKA are required for rotenone resistance in fission yeast. ► Pmk1 and PKA are required for ROS clearance in rotenone treated fission yeast cells. ► PKA plays a role in ROS clearance under normal growth conditions in fission yeast.