Mouse embryonic fibroblasts from CD38 knockout mice are resistant to oxidative stresses through inhibition of reactive oxygen species production and Ca2+ overload

► CD38-deficient MEFs were more resistant to oxidative stress than WT MEFs. ► CD38-knockout appeared to block the production of ROS and elevation of Nox1 mRNA level after hypoxia/reoxygenation. ► CD38-knockout blocked the burst of [Ca2+]i induced by oxidative stress in MEFs. ► The transcriptional activity of Nox1 may be positively influenced by intracellular [Ca2+]. ► The lower expression of Nox1 mRNA in CD38-/- MEFs during oxidative stress might be contributed by a lower [Ca2+]i.