Intrinsic molecular properties of the protein-protein bridge facilitate ratchet-like motion of the ribosome

► The role of the local molecular organization in ratchet-like motion of the ribosome. ► Functional significance of different conformations of b1b in ribosome structures. ► Stability of different constellations of b1b from electrostatic potential maps. ► Intrinsic dynamics of the bridge by NMA describing observed conformational change. ► Participation of L31 in the control of ratcheting and in stabilizing the positions.