کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10765560 1050593 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The transmembrane nucleoporin NDC1 is required for targeting of ALADIN to nuclear pore complexes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The transmembrane nucleoporin NDC1 is required for targeting of ALADIN to nuclear pore complexes
چکیده انگلیسی
NDC1 is a transmembrane nucleoporin that is required for NPC assembly and nucleocytoplasmic transport. We show here that NDC1 directly interacts with the nucleoporin ALADIN, mutations of which are responsible for triple-A syndrome, and that this interaction is required for targeting of ALADIN to nuclear pore complexes (NPCs). Furthermore, we show that NDC1 is required for selective nuclear import. Our findings suggest that NDC1-mediated localization of ALADIN to NPCs is essential for selective nuclear protein import, and that abrogation of the interaction between ALADIN and NDC1 may be important for the development of triple-A syndrome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 389, Issue 1, 6 November 2009, Pages 100-104
نویسندگان
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