کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10765805 1050601 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Telomerase reverse transcriptase activates the expression of vascular endothelial growth factor independent of telomerase activity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Telomerase reverse transcriptase activates the expression of vascular endothelial growth factor independent of telomerase activity
چکیده انگلیسی
Telomerase is almost universally required for cellular immortality and is permissive for tumorigenesis. Accumulating evidence suggests that telomerase may have roles in cellular processes independent of its role in telomere maintenance. However, the biochemical properties and the mechanisms of telomerase non-telomeric functions are unknown. In this report, we show that the telomerase catalytic component hTERT is capable of activating transcription of VEGF. We further demonstrated that the activation of VEGF expression by hTERT was independent of telomerase activity and telomere maintenance. These results suggest that hTERT has non-telomeric activity in the regulation of gene expression and provide additional insights into the role of telomerase in aging and cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 386, Issue 4, 4 September 2009, Pages 739-743
نویسندگان
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