کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10766344 | 1050646 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analysis of DNA variations in promoter region of HCNP gene with Alzheimer's disease
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
hippocampal cholinergic neurostimulating peptide precursor proteinAlzheimer’s disease - بیماری آلزایمرphosphatidylethanolamine binding protein - پروتئین اتصال فسفاتیدیلتانولامینPromoter - پروموترSingle nucleotide polymorphisms - پلیمورفیسم تک نوکلئوتیدیhippocampal cholinergic neurostimulating peptide - پپتید نئواستروژن کولینرژیک هیپوکامپ
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Analysis of DNA variations in promoter region of HCNP gene with Alzheimer's disease Analysis of DNA variations in promoter region of HCNP gene with Alzheimer's disease](/preview/png/10766344.png)
چکیده انگلیسی
Hippocampal cholinergic neurostimulating peptide (HCNP), which enhances acetylcholine synthesis and induces cholinergic phenotype development of the septohippocampal system, is derived from HCNP precursor protein (HCNPpp), also known as phosphatidylethanolamine binding protein (PEBP) and Raf kinase inhibitor protein (RKIP). Our previous study demonstrated that expression of HCNPpp mRNA was decreased in the hippocampi of autopsied brains of Alzheimer's disease (AD) patients, indicating the association of HCNP with the pathogenesis of AD. To clarify the involvement of gene variations in the promoter region of the gene encoding HCNPpp in this mRNA reduction, we analyzed DNA polymorphisms or mutations within this gene promoter region in AD patients by direct sequencing. The promoter was found to contain a CpG island without a TATA box, an element of housekeeping gene promoters. Moreover, no disease-specific polymorphisms or mutations were identified, suggesting that the decrease of mRNA can be ascribed to transcriptional or posttranscriptional changes in activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 379, Issue 2, 6 February 2009, Pages 272-276
Journal: Biochemical and Biophysical Research Communications - Volume 379, Issue 2, 6 February 2009, Pages 272-276
نویسندگان
Kenji Okita, Noriyuki Matsukawa, Mina Maki, Hideka Nakazawa, Eiichi Katada, Manabu Hattori, Hiroyasu Akatsu, Cesario V. Borlongan, Kosei Ojika,