کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10766428 | 1050646 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Early lethality of β-1,4-galactosyltransferase V-mutant mice by growth retardation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
The β-1,4-galactosyltransferase (β-1,4-GalT) V whose human and mouse genes were cloned by us has been suggested to be involved in the biosynthesis of N-glycans and O-glycans, and lactosylceramide. To determine its biological function, β-1,4-GalT V (B4galt5) mutant mice obtained by a gene trap method were analyzed. Analysis of pre- and post-implantation embryos revealed that the B4galt5â/â mice die by E10.5 while B4galt5+/â mice were born and grown normally. Histological study showed that most tissues are formed in B4galt5â/â embryos but their appearance at E10.5 is close to that of B4galt5+/â embryos at E9.0-9.5. The results indicate that the growth is delayed by one to one and half day in B4galt5â/â embryos when compared to B4galt5+/â embryos, which results in early death of the embryos by E10.5, probably due to hematopoietic and/or placental defects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 379, Issue 2, 6 February 2009, Pages 456-459
Journal: Biochemical and Biophysical Research Communications - Volume 379, Issue 2, 6 February 2009, Pages 456-459
نویسندگان
Tadahiro Kumagai, Minoru Tanaka, Minesuke Yokoyama, Takeshi Sato, Tadashi Shinkai, Kiyoshi Furukawa,