کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10767240 1050718 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus
چکیده انگلیسی
The field of epigenetics has made progress by the identification of the small RNA-mediated epigenetic modification. However, little is known about the key proteins. Here, we report that the human PIWI-like family is a candidate protein that is involved in the pathway responsible for chromatin remodeling. The PIWI-like family proteins, expressed as the Flag-fusion proteins, formed a bulky body and localized to the nuclear periphery. Transient transfection of PIWI-like 4 (PIWIL4), only member of the PIWI-like family that was ubiquitously expressed in human tissues, induced histone H3 lysine 9 methylation at the p16Ink4a (CDKN2A) locus. The elevated level of histone methylation resulted in the downregulation of the p16Ink4a gene. These results suggest PIWIL4 plays important roles in the chromatin-modifying pathway in human somatic cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 359, Issue 3, 3 August 2007, Pages 497-502
نویسندگان
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