کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10767721 | 1050795 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Beyond vasodilation: The antioxidant effect of adrenomedullin in Dahl salt-sensitive rat aorta
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Beyond vasodilation: The antioxidant effect of adrenomedullin in Dahl salt-sensitive rat aorta Beyond vasodilation: The antioxidant effect of adrenomedullin in Dahl salt-sensitive rat aorta](/preview/png/10767721.png)
چکیده انگلیسی
We have investigated the antioxidant effect of adrenomedullin (AM) on endothelial function in the Dahl salt-sensitive (DS) rat hypertension model. Dahl salt-resistant (DR) and DS rats were fed an 8% NaCl diet. In addition, the DS rats were subcutaneously infused with either saline or recombinant human AM for 4 weeks. Although systolic blood pressures measured weekly in AM- and saline-infused rats did not significantly differ, aortic O2â levels were significantly (PÂ <Â 0.01) higher in the latter. Likewise, both endothelial nitric oxide synthase (eNOS) mRNA and protein were significantly higher in saline-infused DS rats. Infusion of AM reduced both O2â and eNOS expression to levels comparable to those seen in DR rats. AM infusion also upregulated the gene expression of guanosine-5â²-triphosphate cyclohydrolase I and downregulated the expression of p22phox, suggesting that AM increased the NOS coupling and bioavailability of NO. AM possesses significant antioxidant properties that improve endothelial function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 332, Issue 3, 8 July 2005, Pages 866-872
Journal: Biochemical and Biophysical Research Communications - Volume 332, Issue 3, 8 July 2005, Pages 866-872
نویسندگان
Yuan-Ning Cao, Kenji Kuwasako, Johji Kato, Toshihiko Yanagita, Toshihiro Tsuruda, Junichi Kawano, Yasuko Nagoshi, Alex F. Chen, Akihiko Wada, Tatsuo Suganuma, Tanenao Eto, Kazuo Kitamura,