کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10767862 1050801 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Blockade of γ-secretase activity within the hippocampus enhances long-term memory
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Blockade of γ-secretase activity within the hippocampus enhances long-term memory
چکیده انگلیسی
The γ-secretase complex, a membrane-bound aspartyl protease, hydrolyzes the transmembrane domains of several integral membrane proteins including the key signaling molecules amyloid precursor protein (APP), Notch, deleted in colorectal cancer (DCC), and N- and E-cadherins. The proteolysis processing of these proteins is critical for generation of signaling molecules that may participate in neuronal communication and plasticity. Using a potent γ-secretase inhibitor, L-685,458, we examined if blockade of its activity in the hippocampus can influence contextual and spatial memory in rats. Surprisingly, we observed that post-training blockade of γ-secretase activity leads to enhanced long-term memory in two hippocampus-dependent tasks. This suggests that a signaling molecule(s) generated by γ-secretase activity may have a negative influence on long-term memory formation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 338, Issue 2, 16 December 2005, Pages 777-782
نویسندگان
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