کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10768088 | 1050803 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transformation of mouse fibroblasts alters the induction pattern of type I IFNs after virus infection
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Transformation of mouse fibroblasts alters the induction pattern of type I IFNs after virus infection Transformation of mouse fibroblasts alters the induction pattern of type I IFNs after virus infection](/preview/png/10768088.png)
چکیده انگلیسی
Type I interferons (IFNs) have been shown to be involved in many immune defence and inflammatory responses. We here show that IFN-β plays an absolute essential role in the efficient induction of all type I IFNs after infection of primary embryonic as well as primary adult fibroblasts with Sendai virus. In contrast, after immortalization of such fibroblasts with SV40 large T antigen, IFN-α4 can be induced independently of IFN-β. However, efficient secretion of type I IFNs even in immortalized fibroblasts is only found when the complete signalling loop is induced by IFN-β.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 335, Issue 2, 23 September 2005, Pages 584-589
Journal: Biochemical and Biophysical Research Communications - Volume 335, Issue 2, 23 September 2005, Pages 584-589
نویسندگان
Christofer V. Samuelsson, Stefan Lienenklaus, Peter P. Müller, Rainer Zawatzky, Hansjörg Hauser, Siegfried Weiss,