کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10768217 1050804 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
30 some years of heme oxygenase: From a “molecular wrecking ball” to a “mesmerizing” trigger of cellular events
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
30 some years of heme oxygenase: From a “molecular wrecking ball” to a “mesmerizing” trigger of cellular events
چکیده انگلیسی
In the beginning, the microsomal HO system was presumed to be made of one isozymes, now known as HO-1, which was cytP450-dependent; and, was thought to be of physiological significance solely in the context of catalysis of hemoglobin heme to bile pigments and CO. A succession of discoveries including characterization of the system as an independent mono-oxygenase, identification of a second form, called HO-2, free radical quenching activity of bile pigments, analogous function of CO in cell signaling to NO, and characterization of the system as HSP32 cognates has led to such an impressive expansion in the number of reports dealing with the HO system that surpass anyone's expectation. This review is a compilation of certain older findings and recent events that together ensure placement of the HO system in the mainstream research for decades to come.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 338, Issue 1, 9 December 2005, Pages 568-577
نویسندگان
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