کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10768907 1050816 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
GABAergic disinhibition facilitates polysynaptic excitatory transmission in rat anterior cingulate cortex
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
GABAergic disinhibition facilitates polysynaptic excitatory transmission in rat anterior cingulate cortex
چکیده انگلیسی
Various studies implicate the anterior cingulate cortex (ACC) in processing pain. Combining whole-cell patch clamp recordings in rat ACC slices and a formalin-induced conditioned place avoidance (F-CPA) behavioral model, the present study was to address the effect of GABAA receptors on excitatory transmission to ACC layer V neurons and its possible functional significance related to pain. Removal of GABAA inhibition by bicuculline (10 μM) induced a novel long-lasting response in layer V neurons, which could be blocked by high divalent extracellular solution and was sensitive to relatively higher rate stimuli. Co-application of NMDA receptor antagonist APV (50 μM) and non-NMDA receptor antagonist DNQX (10 μM) completely blocked the responses. Enhancement of inhibition by intra-ACC microinjection of muscimol abolished the acquisition of F-CPA without affecting formalin-induced acute nociceptive responses. These results suggest that GABAA inhibition may be involved in pain-related aversion by modulating glutamate-mediated excitatory transmission in the ACC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 338, Issue 3, 23 December 2005, Pages 1634-1639
نویسندگان
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