کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10769179 1050820 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Allelic variation in the serotonin transporter (5HTT) gene contributes to idiopathic pulmonary hypertension in children
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Allelic variation in the serotonin transporter (5HTT) gene contributes to idiopathic pulmonary hypertension in children
چکیده انگلیسی
Pulmonary hypertension is a potentially lethal condition, which affects adults and children alike. Genetic factors are implicated in the causation of primary pulmonary hypertension. We investigate the role of polymorphism in the 5HTT gene in the etiology of pulmonary hypertension in children aged 1-18.8 years. We have tested the hypothesis that the 5HTT gene does contribute to the pathogenesis of this disease in children by comparing the allelic frequencies of both the long and short variants between children with idiopathic pulmonary hypertension and pulmonary hypertension secondary to underlying pulmonary disease. We found that homozygosity for the long variant of 5HTT was highly associated with idiopathic pulmonary hypertension in children, suggesting perhaps a more important role for 5HTT gene function in the pathogenesis of early onset disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 334, Issue 2, 26 August 2005, Pages 376-379
نویسندگان
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