کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10769489 | 1050822 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel function of transcription factor α-Pal/NRF-1: Increasing neurite outgrowth
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
α-Pal/NRF-1 is a critical regulator of the promoter of human IAP/CD47 gene, a gene related to memory formation in rodents. However, its function in neurons was unknown. We found that stable or transient expression of full-length α-Pal/NRF-1 in human neuroblastoma IMR-32 cells significantly induced neurite outgrowth and increased the length of neurites both in medium containing 10% fetal bovine serum and in serum-free medium. In contrast, the dominant-negative mutant of α-Pal/NRF-1 inhibited the induction and extension of neurites. Ectopic expression of full-length α-Pal/NRF-1 also increased the induction of neurite outgrowth in primary mouse cortical neurons. The IAP antisense cDNA significantly inhibited the increase of neurite outgrowth by α-Pal/NRF-1. These findings indicate that a novel function of α-Pal/NRF-1 is to regulate neuronal differentiation, and that this function is mediated partly via its downstream IAP gene.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 334, Issue 1, 19 August 2005, Pages 199-206
Journal: Biochemical and Biophysical Research Communications - Volume 334, Issue 1, 19 August 2005, Pages 199-206
نویسندگان
Wen-Teng Chang, Hsiun-ing Chen, Rong-Jing Chiou, Chen-Yun Chen, A-Min Huang,