کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10769862 | 1050826 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Decrease in glucose-stimulated insulin secretion following exposure to magnetic fields
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Decrease in glucose-stimulated insulin secretion following exposure to magnetic fields Decrease in glucose-stimulated insulin secretion following exposure to magnetic fields](/preview/png/10769862.png)
چکیده انگلیسی
We evaluated the effects of extremely low frequency magnetic field (ELFMF) on glucose-stimulated insulin secretion from HIT-T15 cells and investigated the mechanisms of these effects. We demonstrated that exposure to ELFMF at 5Â mT decreased glucose-stimulated insulin secretion by preventing the increases in cellular adenosine 5â²-triphosphate/adenosine 5â²-diphosphate, membrane depolarization, and cytosolic free calcium ion concentration. The glucose-induced upregulation of insulin mRNA expression was also attenuated by exposure to ELFMF, although cell viability was not affected. These findings demonstrate the potential of exposure to ELFMF for clinical use as a novel inhibitory method of insulin secretion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 332, Issue 1, 24 June 2005, Pages 28-32
Journal: Biochemical and Biophysical Research Communications - Volume 332, Issue 1, 24 June 2005, Pages 28-32
نویسندگان
Tomonori Sakurai, Shin Koyama, Yoshiki Komatsubara, Wang Jin, Junji Miyakoshi,