کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10770052 | 1050828 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Crystal structure of heterotetrameric sarcosine oxidase from Corynebacterium sp. U-96
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Crystal structure of heterotetrameric sarcosine oxidase from Corynebacterium sp. U-96 Crystal structure of heterotetrameric sarcosine oxidase from Corynebacterium sp. U-96](/preview/png/10770052.png)
چکیده انگلیسی
Sarcosine oxidase from Corynebacterium sp. U-96 is a heterotetrameric enzyme. Here we report the crystal structures of the enzyme in complex with dimethylglycine and folinic acid. The α subunit is composed of two domains, contains NAD+, and binds folinic acid. The β subunit contains dimethylglycine, FAD, and FMN, and these flavins are approximately 10 Ã
apart. The γ subunit is in contact with two domains of α subunit and has possibly a folate-binding structure. The δ subunit contains a single atom of zinc and has a Cys3His zinc finger structure. Based on the structures determined and on the previous works, the structure-function relationship on the heterotetrameric sarcosine oxidase is discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 333, Issue 2, 29 July 2005, Pages 359-366
Journal: Biochemical and Biophysical Research Communications - Volume 333, Issue 2, 29 July 2005, Pages 359-366
نویسندگان
Koh Ida, Tomotaka Moriguchi, Haruo Suzuki,