کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10770105 | 1050829 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hepatic steatosis in transgenic mice overexpressing human histone deacetylase 1
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
It is generally thought that histone deacetylases (HDACs) play important roles in the transcriptional regulation of genes. However, little information is available concerning the specific functions of individual HDACs in disease states. In this study, two transgenic mice lines were established which harbored the human HDAC1 gene. Overexpressed HDAC1 was detected in the nuclei of transgenic liver cells, and HDAC1 enzymatic activity was significantly higher in the transgenic mice than in control littermates. The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism. Molecular studies showed that HDAC1 may contribute to nuclear pleomorphism through the p53/p21 signaling pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 330, Issue 2, 6 May 2005, Pages 461-466
Journal: Biochemical and Biophysical Research Communications - Volume 330, Issue 2, 6 May 2005, Pages 461-466
نویسندگان
Ai-Guo Wang, Sang-Beom Seo, Hyung-Bae Moon, Hye-Jun Shin, Dong Hoon Kim, Jin-Man Kim, Tae-Hoon Lee, Ho Jeong Kwon, Dae-Yeul Yu, Dong-Seok Lee,