کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10770826 | 1050836 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Calcitonin receptor-stimulating peptide-1 regulates ion transport and growth of renal epithelial cell line LLC-PK1
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Calcitonin receptor-stimulating peptide-1 regulates ion transport and growth of renal epithelial cell line LLC-PK1 Calcitonin receptor-stimulating peptide-1 regulates ion transport and growth of renal epithelial cell line LLC-PK1](/preview/png/10770826.png)
چکیده انگلیسی
Calcitonin receptor-stimulating peptide-1 (CRSP-1) is a peptide recently identified from porcine brain by monitoring the cAMP production through an endogenous calcitonin (CT) receptor in the renal epithelial cell line LLC-PK1. Here we investigated the effects of CRSP-1 on the ion transport and growth of LLC-PK1 cells. CRSP-1 inhibited the growth of LLC-PK1 cells with a higher potency than porcine CT. CRSP-1 enhanced the uptake of 22Na+ into LLC-PK1 cells more strongly than did CT and slightly reduced the 45Ca2+ uptake. The enhancement of the 22Na+ uptake was abolished by 5-(N-ethyl-N-isopropyl) amiloride, a strong Na+/H+ exchanger (NHE) inhibitor for NHE1, even at a concentration of 1Â ÃÂ 10â8Â M, although other ion transporter inhibitors did not affect the 22Na+ uptake. These results indicate that CRSP-1 enhances the 22Na+ uptake by the specific activation of NHE1. Taken together, CRSP-1 is considered to be a new regulator for the urinary ion excretion and renal epithelial cell growth.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 330, Issue 1, 29 April 2005, Pages 75-80
Journal: Biochemical and Biophysical Research Communications - Volume 330, Issue 1, 29 April 2005, Pages 75-80
نویسندگان
Kazumasa Hamano, Takeshi Katafuchi, Katsuro Kikumoto, Naoto Minamino,