کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10771400 1050841 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
tRNAPhe cleavage by aminoglycosides is triggered off by formation of an abasic site
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
tRNAPhe cleavage by aminoglycosides is triggered off by formation of an abasic site
چکیده انگلیسی
This communication reports the characteristics of the mechanism of highly specific tRNAPhe cleavage, which occurs in the anticodon loop in the presence of aminoglycoside antibiotic-neomycin B. The data prove that the cleavage requires previous depurination of the polynucleotide chain at position 37, which is occupied by a hypermodified guanine base-wybutine. The results suggest that the phenomenon, previously considered as selective with respect to the presence of tRNA hypermodification, may concern far more RNA molecules, namely the ones carrying abasic sites.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 331, Issue 1, 27 May 2005, Pages 267-271
نویسندگان
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