کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10771460 | 1050842 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PKCε induces interleukin-6 expression through the MAPK pathway in 3T3-L1 adipocytes
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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![عکس صفحه اول مقاله: PKCε induces interleukin-6 expression through the MAPK pathway in 3T3-L1 adipocytes PKCε induces interleukin-6 expression through the MAPK pathway in 3T3-L1 adipocytes](/preview/png/10771460.png)
چکیده انگلیسی
Recent reports have suggested that PKCε contributes to systemic insulin resistance, and is involved in the pathogenesis of type 2 diabetes, however, the exact mechanism is still unknown. To elucidate the possible involvement of PKCε in the pathogenesis of type 2 diabetes, we examined the role of PKCε in differentiated adipocytes using mouse 3T3-L1 adipocytes. We found that the over-expression of PKCε resulted in the increase of IL-6 expression in differentiated adipocytes. This PKCε-induced IL-6 expression could be completely inhibited by U0126, an inhibitor of mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase. We also demonstrated that PKCε increased the transcriptional activity of Est-like transcription factor (Elk-1) as well as the DNA-binding activity of activator protein-1 (AP-1) in differentiated 3T3-L1 adipocytes. These results suggest that PKCε is able to increase IL-6 expression via the ERK-AP-1 pathway in differentiated adipocytes, and that PKCε is involved in systemic insulin resistance by regulating plasma IL-6 concentrations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 327, Issue 3, 18 February 2005, Pages 707-712
Journal: Biochemical and Biophysical Research Communications - Volume 327, Issue 3, 18 February 2005, Pages 707-712
نویسندگان
Kana Ohashi, Akio Kanazawa, Shuichi Tsukada, Shiro Maeda,