کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10771932 1050845 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
C/EBPα reverses the anti-adipogenic effects of the HIV protease inhibitor nelfinavir
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
C/EBPα reverses the anti-adipogenic effects of the HIV protease inhibitor nelfinavir
چکیده انگلیسی
Nelfinavir and other HIV protease inhibitors effectively suppress morbidity and mortality in HIV-infected patients. However, therapeutic use of HIV protease inhibitors has been temporally associated with the development of a lipodystrophy/insulin resistance syndrome and some evidence suggests that HIV protease inhibitors may be the causative agent. We report here that nelfinavir promotes loss of cytoplasmic triglyceride from fully differentiated adipocytes and inhibits preadipocyte differentiation at biologically relevant concentrations. Forced expression of the adipogenic transcription factor C/EBPα rescues some of the anti-adipogenic effects of nelfinavir. These results suggest that nelfinavir may mediate an anti-adipogenic effect by antagonizing expression of C/EBPα.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 327, Issue 2, 11 February 2005, Pages 571-574
نویسندگان
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