کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10795411 1052582 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila
چکیده انگلیسی
An assembled cDNA coding for the putative single-subunit NADH dehydrogenase (NDX) of Ciona intestinalis was introduced into Drosophila melanogaster. The encoded protein was found to localize to mitochondria and to confer rotenone-insensitive substrate oxidation in organello. Transgenic flies exhibited increased resistance to menadione, starvation and temperature stress, and manifested a sex and diet-dependent increase in mean lifespan of 20-50%. However, NDX was able only weakly to complement the phenotypes produced by the knockdown of complex I subunits.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1837, Issue 11, November 2014, Pages 1861-1869
نویسندگان
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