کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10795423 1052583 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Superoxide production by cytochrome bc1 complex: A mathematical model
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Superoxide production by cytochrome bc1 complex: A mathematical model
چکیده انگلیسی
Reactive oxygen species (ROS) are involved in the pathophysiology of several diseases (e.g. Alzheimer or atherosclerosis) and also in the aging process. The main source of ROS in aerobic organisms is the electron transport chain (ETC) in the inner mitochondrial membrane. Superoxide is produced at complexes I and III of the ETC, starting a complex network of ROS reactions. To achieve a deeper mechanistic understanding of how ROS are generated by complex III, we developed a mathematical model that successfully describes experimental data of complex III activity in various rat tissues, the production of ROS with and without antimycin and ROS generation depending on different values of the membrane potential ∆Ψ. The model also reinforces the idea of ubiquinone acting as a redox mediator between heme bL and oxygen, as proposed earlier.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1837, Issue 10, October 2014, Pages 1643-1652
نویسندگان
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