کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10796533 1053168 2016 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hit 'em where it hurts: The growing and structurally diverse family of peptides that target lipid-II
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Hit 'em where it hurts: The growing and structurally diverse family of peptides that target lipid-II
چکیده انگلیسی
Understanding the mode of action of antibiotics is becoming more and more important in the time that microorganisms start to develop resistance. One very well validated target of several classes of antibiotics is the peptidoglycan precursor lipid II. In this review different classes of lipid II targeting antibiotics will be discussed in detail, including the lantibiotics, human invertebrate defensins and the recently discovered teixobactin. By hitting bacteria where it hurts, at the level of lipid II, we expect to be able to develop efficient antibacterial agents in the future. This article is part of a Special Issue entitled: Antimicrobial peptides edited by Karl Lohner and Kai Hilpert.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1858, Issue 5, May 2016, Pages 947-957
نویسندگان
, , ,