Electrical potentiation of the membrane permeabilization by new peptides with anticancer properties

► The hepta-arginine vector was conjugated to natural fragments of the Cry11Bb protoxin. ► Conjugated peptides were highly active in the permeabilization of isolated mitochondria. ► External electrical pulses increased the plasma membrane permeabilization by the peptides. ► The designed peptides selectively killed Jurkat cells, but not CHO cells.