Structural and functional studies on a proline-rich peptide isolated from swine saliva endowed with antifungal activity towards Cryptococcus neoformans

► A proline-rich peptide has been isolated from swine saliva possessing antifungal activity. ► It is not cytoxocic towards human control cells. ► It does not show membrane damaging effects, but it is internalized within yeast cells. ► Its structural chracteristcs suggest that this peptide may act through the interaction with an intracellular target.