Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca2Â +-dependent pathway

► LA increases the activity of HCs formed by Cxs 26, 32, 43 and 45. ► LA induces a rise of intracellular free Ca2 + and activation of a PI3K/Akt-dependent pathway. ► Cx26 HCs mediate the Ca2 + influx to the cells in response to LA. ► Cx26 HCs are sensitive to a reducing environment.