Ion solvation and structural stability in a sodium channel investigated by molecular dynamics calculations

► We study the stability and ion binding properties of a sodium ion channel (NavAb). ► Sodium ions in the selectivity filter are highly hydrated. ► Sodium ions bind with the channel protein in an asymmetric manner. ► Robust stability of the NavAb channel ► Ion permeation through NavAb can be induced by an electric field above 0.5 V/nm.