Comparing ion conductance recordings of synthetic lipid bilayers with cell membranes containing TRP channels

► We compare electrical recordings from lipid bilayers with those from TRP channels. ► Artificial membranes display conductance events similar to those of TRP channels. ► We find bursts, flickering, multiple steps, and spikes in both preparations. ► The time scale and conductance in both preparations are of similar order. ► Conduction in artificial membranes is facilitated by the melting transition.