Calcium-dependent aggregation and fusion of phosphatidylcholine liposomes induced by complexes of flavonoids with divalent iron

►We studied interaction of flavonoid-iron(II) complexes with liposomes. ►We found that flavonoid-iron(II) can initiate aggregation of liposomes. ►Calcium facilitates aggregation and fusion of liposomes treated by flavonoid-iron. ►We concluded that iron(II) produces links between bilayers contained flavonoids.