The effect of aliphatic alcohols on fluid bilayers in unilamellar DOPC vesicles - A small-angle neutron scattering and molecular dynamics study

► Neutron scattering and molecular dynamics study on structural parameters of DOPC + DOPS + CnOH (n = 8-18) bilayers. ► Bilayer thickness decreases with CnOH:PCPS molar ratio and increases with CnOH chain length. ► Lateral area of the unit cell significantly increases already in the presence of C8OH. ► Alcohol partial interfacial area in bilayers increases linearly with the alkyl chain length. ► Alcohol partial interfacial area obtained for CnOHs with n ≤ 10 corresponds to ACnOH ≤ 20 Å2.