Cholesterol attenuates and prevents bilayer damage and breakdown in lipoperoxidized model membranes. A spin labeling EPR study

► 40% Cholesterol in lipoperoxidized planar membranes prevents fatty acid disorienting. ► 40% Cholesterol in oxidized phospholipid vesicles counteracts membrane breakdown. ► Cholesterol maintains bilayer ordering and preserves membrane integrity in lipoperoxidation.