Influence of the lipid composition of biomimetic monolayers on the structure and orientation of the gp41 tryptophan-rich peptide from HIV-1

► Gp41W is the Trp-rich peptide of the HIV-1 glycoprotein 41. ► Its interaction with DPPC, DPPC/Chol and DPPG monolayers is surface pressure-dependent. ► Gp41W keeps its α-helix conformation in the presence of DPPG monolayers.