Sodium-calcium exchanger and lipid rafts in pig coronary artery smooth muscle

► Lipid rafts in the plasma membrane of coronary artery smooth muscle are of two types. ► The first type of lipid rafts are rich in caveolin and flotillin. ► The second type is rich in cholesterol, GM gangliosides and prion proteins. ► NCX1 and SERCA2 are co-localized in the first. ► NCX1-SERCA2 co-localization may aid in cell signaling.