Relationship between membrane permeability and specificity of human secretory phospholipase A2 isoforms during cell death

► Early apoptotic cells display modest permeability to propidium iodide ► These cells are susceptible to hydrolysis by secretory phospholipase A2 (sPLA2) ► Cells dying by acute calcium loading do not show the modest permeability ► The differences in permeability corresponds to specificity of human sPLA2 isoforms