Effects of the antimalarial drug primaquine on the dynamic structure of lipid model membranes

► PQ changes the equilibrium constant between DMPC gel-like and fluid-like domains. ► The dynamic structure and volumetric properties of membranes are affected by PQ. ► PQ promotes PC headgroup ordering and PE positive membrane curvature. ► Interactions with membranes may play an important role to the PQ mechanism of action.