کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10797991 | 1053234 | 2011 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A plausible mode of action of pseudin-2, an antimicrobial peptide from Pseudis paradoxa
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A plausible mode of action of pseudin-2, an antimicrobial peptide from Pseudis paradoxa A plausible mode of action of pseudin-2, an antimicrobial peptide from Pseudis paradoxa](/preview/png/10797991.png)
چکیده انگلیسی
âºWe found that pseudin-2 organized to an aggregated state in aqueous solution, but that it dissociated into monomers upon binding to lipopolysaccharide (LPS), even though it did not neutralize LPS in Gram-negative bacteria. âºpseudin-2 assumed an α-helical structure in the presence of biological membranes and formed pores in both bacterial and fungal membranes, through which it entered the cytoplasm and tightly bound to RNA. âºThe potent antimicrobial activity of pseudin-2 likely results from both the formation of pores capable of collapsing the membrane potential and releasing intracellular materials and its inhibition of macromolecule synthesis through its binding to RNA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1808, Issue 1, January 2011, Pages 171-182
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1808, Issue 1, January 2011, Pages 171-182
نویسندگان
Seong-Cheol Park, Jin-Young Kim, Chanyoung Jeong, Suyeon Yoo, Kyung-Soo Hahm, Yoonkyung Park,