کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10798917 1054208 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Linker histones: History and current perspectives
ترجمه فارسی عنوان
هیستونهای لینکدار: تاریخ و چشم اندازهای جاری
کلمات کلیدی
کروماتین، هسته هسته، هیستون لینکر،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Although the overall structure of the fifth histone (linker histone, H1) is understood, its location on the nucleosome is only partially defined. Whilst it is clear that H1 helps condense the chromatin fibre, precisely how this is achieved remains to be determined. H1 is not a general gene repressor in that although it must be displaced from transcription start sites for activity to occur, there is only partial loss along the body of genes. How the deposition and removal of H1 occurs in particular need of further study. Linker histones are highly abundant nuclear proteins about which we know too little. This article is part of a Special Issue entitled: Histone H1, edited by Dr. Albert Jordan.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1859, Issue 3, March 2016, Pages 431-435
نویسندگان
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