The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states

► The Paf1 complex associates with RNA polymerase II on all active genes examined. ► The Paf1 complex couples conserved histone modifications to transcript elongation. ► The Paf1 complex regulates post-transcriptional events in gene expression. ► In higher eukaryotes, the Paf1 complex has diverse functions in cell cycle control, development, and disease.