The long and the short of it: The role of the zinc finger polyadenosine RNA binding protein, Nab2, in control of poly(A) tail length

► Transcript poly(A) tails of correct length are critical for proper gene expression. ► Nab2 is an essential nuclear polyadenosine binding protein in S. cerevisiae. ► Nab2 is important for control of poly(A) tail length of RNA transcripts. ► The Drosophila Nab2 homologue, dNab2, is critical for neuronal function in flies. ► Mutations in the gene encoding human Nab2, ZC3H14, cause intellectual disability.