کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10799761 | 1054591 | 2016 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Towards personalized diagnostics via longitudinal study of the human plasma N-glycome
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
To evaluate this, we collected blood plasma samples of five healthy donors over a time period of up to six years (min. 1.5Â years). The plasma N-glycome was analyzed by xCGE-LIF, to investigate the intra-individual N-glycome variability over time. It is shown, that the plasma N-glycome of an individual is remarkably stable over a period of several years, and that observed small longitudinal changes are independent from seasons, but significantly correlated with lifestyle and environmental factors. Thus, the potential of future longitudinal biomarker discovery studies could be demonstrated, which is a further step towards personalized diagnostics. This article is part of a Special Issue entitled “Glycans in personalised medicine” Guest Editor: Professor Gordan Lauc.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - General Subjects - Volume 1860, Issue 8, August 2016, Pages 1728-1738
Journal: Biochimica et Biophysica Acta (BBA) - General Subjects - Volume 1860, Issue 8, August 2016, Pages 1728-1738
نویسندگان
René Hennig, Samanta Cajic, Matthias Borowiak, Marcus Hoffmann, Robert Kottler, Udo Reichl, Erdmann Rapp,