Interaction of human telomeric G-quadruplex DNA with thymoquinone: A possible mechanism for thymoquinone anticancer effect

TQ is intercalated to human telomere G-quadruplex on two binding sites close to (a) T17, T18 and A19 loop with grid score of − 19.5 kcal/mol (low affinity site) and to (b) T11, T12 and A13 loop with grid score of − 26.2 kcal/mol (high affinity site). Docking of TQ on G-quadruplex structure using Dock 6.62